Diablo III
No word on release date yet but knowing Blizzard dispite having very nice screenshots and video of ingame footage its not likely to be this year and even late next year might be pushing it. No console version either, just PC and Mac. Isometric view stays the same and a fully destructible environment. Drop in co-op and can play with AI party members if you have no friends. Maps will be mix of random and static, its also not a persistent world and subscription fee unlikely